Glutamate and SYM2081 potency at NR2A/D chimeric receptor constructs
Receptor Construct | Glutamate | SYM2081 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EC50 | EC50 NR2(Chim)/NR2D(WT) | Hill Slope | n | EC50 | EC50 NR2(Chim)/NR2D(WT) | Hill Slope | n | |||||||
| μM | μM | |||||||||||||
| Wild-type NR2A | 3.3 | 7 | 1.1 | 26 | 144 | 46 | 1.2 | 12 | ||||||
| Wild-type NR2D | 0.49 | 1.5 | 30 | 3.2 | 1.3 | 13 | ||||||||
| NR2A(2D-S1) | 0.68 | 1.4 | 1.0 | 27 | 5.9 | 1.9 | 1.6 | 8 | ||||||
| NR2A(2D-S2) | 0.64 | 1.3 | 1.0 | 26 | 20 | 6.4 | 1.3 | 8 | ||||||
| NR2A(2D-S1S2) | 0.50 | 1.0 | 1.0 | 26 | 3.8 | 1.2 | 1.2 | 6 | ||||||