TABLE 2

Potential molecular interactions between apoE_141–148 and the α7 nAChR

apoE_141–148	α7 nAChR	Subunit	Potential Interaction	Distance
				Å
L141	Ser34^a	Complementary	VDW	3.3
L141	Leu35	Complementary	Hydrophobic	4.0
L141	Ser36	Complementary	VDW	3.0
L141	Trp55^a	Complementary	Hydrophobic	3.3
L141	Gln57	Complementary	VDW	3.1
L141	Leu119	Complementary	Hydrophobic	3.1
L141	Met160	Complementary	H bond	2.7
R142	Met160	Complementary	H bond	2.7
L144	Trp55^a	Complementary	Hydrophobic	3.7
L144	Gln57	Complementary	VDW	2.7
R145	Leu37	Complementary	H bond	2.0/2.8
R145	Leu38	Complementary	H bond	2.6/2.7
R145	Glu162^a	Complementary	H bond	2.2/2.9/2.9
R145	Ser167	Complementary	H bond	2.9
K146	Lys186^a	Principal	H bond	2.4
R147	Lys186^a	Principal	H bond	1.8
L148	Trp55^a	Complementary	Hydrophobic	1.6
L148	Tyr93	Principal	Hydrophobic	4.3
L148	Trp149^a	Principal	Hydrophobic	3.0
L148	Lys186^a	Principal	H bond	3.6
L148	Tyr188^a	Principal	Hydrophobic	4.5
L148	Tyr195^a	Principal	Hydrophobic	3.3