Compound | Concentration | γ-F | β-R | γ/(γ+2β) | Number of Cell Duplications |
---|---|---|---|---|---|
μM | % of control | ||||
1 | 2 | 423.3 | 210.2 | 198.7 | 0.64 ± 0.17 |
2 | 0.6 | 499.5 | 279.6 | 177.1 | 0.69 ± 0.17 |
3 | 2 | 514.4 | 529 | 99 | 0.19 ± 0.17 |
4 | 6 | 25.6 | 134.6 | 19.4 | 2.36 ± 0.17 |
5 | 20 | 167.6 | 242.3 | 68.5 | 2.34 ± 0.17 |
6 | 6 | 179.5 | 178 | 100.3 | 0.96 ± 0.17 |
7 | 2 | 937.7 | 544.4 | 173.8 | 0.34 ± 0.17 |
8 | 2 | 266.5 | 350.8 | 77.5 | 2.42 ± 0.17 |
9 | 2 | 897.9 | 338.5 | 264.8 | 1.07 ± 0.17 |
10 | 0.2 | 78.6 | 94.8 | 83.7 | 1.9 |
11 | 2 | 255.7 | 207.6 | 122.9 | -0.11 ± 0.17 |
12 | Toxic | N.D. | N.D. | N.D. | N.D. |
13 | 0.02 | 95.5 | 83.0 | 114.0 | 2.0 |
14 | 0.2 | 100.2 | 98.5 | 102.4 | 2.2 |
15 | 0.2 | 125.0 | 113.3 | 112.0 | 2.1 |
16 | 0.2 | 167.7 | 115.6 | 142.8 | 2.0 |
17 | 0.2 | 107.2 | 120.1 | 90.0 | 1.0 |
18 | 0.2 | 114.8 | 112.0 | 102.0 | 1.4 |
19 | 0.2 | 99.5 | 98.1 | 100.0 | 1.2 |
20 | 2 | 85.8 | 131.8 | 65.3 | 1.79 |
21 | 0.2 | 181.3 | 178.9 | 101.3 | 0.20 |
22 | 2 | 261.8 | 272.5 | 96.1 | 0.29 |
23 | 2 | 268.6 | 253.7 | 101.3 | -0.70 |
24 | 2 | 117.7 | 234.8 | 50.3 | 0 |
25 | 0.2 | 173.0 | 267.8 | 64.7 | 1.94 |
SAHA | 0.2 | 189.1 | 153.1 | 123.2 | 1.29 |
DMSO | 1% (v/v) | 100 | 100 | 100 | 2.4 ± 0.17 |
N.D., not determined.