Compound | Class I (HDAC1) | Class IIa (HDAC4) |
---|---|---|
% | % | |
SAHA | ||
0.2 μM | 52.2 ± 1.4 | 66.6 ± 1.6 |
2.0 μM | 15.5 ± 1.4 | 33.8 ± 1.1 |
9 | ||
0.2 μM | 108.2 ± 7.1 | 94.3 ± 0.6 |
0.6 μM | 116.0 ± 2.8 | 98.1 ± 0.3 |
2.0 μM | 113.3 ± 4.3 | 89.8 ± 0.7 |
6.0 μM | 107.5 ± 3.9 | 78.0 ± 0.2 |
20 μM | 102.8 ± 2.1 | 41.8 ± 0.8 |
24 | ||
0.2 μM | 55.1 ± 0.7 | 70.3 ± 0.7 |
0.6 μM | 29.8 ± 1.6 | 43.5 ± 0.01 |
2.0 μM | 14.2 ± 0.9 | 30.8 ± 0.6 |
6.0 μM | 9.8 ± 0.07 | 18.4 ± 0.8 |
20 μM | 8.5 ± 0.05 | 17.0 ± 0.6 |