Toxin | DmNav1 | DmNav1 V0.5 | rNav1.4 | rNav1.4 V0.5 |
---|---|---|---|---|
μM | mV | μM | mV | |
Control | -19.1 ± 0.5 | -26 ± 0.2 | ||
Lqh-dprIT3 | 0.2 | -35.4 ± 0.7 | 5 | -31 ± 0.7 |
-50.7 ± 2.3 (23%) | ||||
Lqh-dprIT3E24N | 1 | -20.2 ± 06 | 1 | -38.5 ± 0.3 |
-60.4 ± 1.5 (11%) | ||||
LqhIT2 | 1 | -33.1 ± 0.4 | 5 | -30 ± 0.2 |
-52 ± 3.5 (8%) | ||||
LqhIT2K23A | 5 | -20.8 ± 0.7 | 5 | -27.2 ± 1.5 |
LqhIT2E24A | 5 | -18.6 ± 0.6 | 5 | -33.5 ± 1.5 |
-54.5 ± 9 (15%) | ||||
LqhIT2E24N | 5 | -19 ± -0.5 | 5 | -32.8 ± 1.4 |
|
|
|
| -43.1 ± 4.1 (62%) |