IC50 | Significance | -Fold Change | n | |
---|---|---|---|---|
μM | ||||
WT | 38.14 ± 1.06 | 6–9 | ||
T479A | 0.19 ± 0.04 | P < 0.001 | 200 | 3–8 |
I502A | 92.04 ± 5.54 | P < 0.001 | 2.43 | 3–6 |
I502L | 10.75 ± 1.09 | P < 0.001 | 3.55 | 5–10 |
I502F | 164.49 ± 31.36 | P < 0.001 | 4.13 | 3–6 |
V505A | 13.076 ± 3.58 | P < 0.001 | 2.92 | 4–6 |
V505F | 4.27 ± 0.34 | P < 0.001 | 8.93 | 4–6 |
I508A | 7.39 ± 0.92 | P < 0.001 | 5.15 | 3–9 |
I508F | 74.71 ± 5.37 | P < 0.001 | 1.96 | 4–9 |