TABLE 5

Selected dexamethasone-inducible genes identified in A549 cells

A549 cells were either not treated or treated with dexamethasone (1 μM) for 2, 4, 6 or 18 h. RNA was prepared and microarray analysis performed using recommended Affymetrix methods. Data (n = 3), analyzed using the P-fold algorithm, are presented as relative fold induction (R), verses not treated at each time point. P values are indicated (P).

Gene symbol (common name)	Accession No. (Ref Seq)	Affymetrix ID	2 h			4 h			6 h			18 h
Gene symbol (common name)	Accession No. (Ref Seq)	Affymetrix ID				-fold	P	-fold	P	-fold	P	-fold	P
TSC22D3 (GILZ)	NM_001015881	36629_AT	6.7	<0.001	10.2	<0.001	18.9	<0.001	3.47	0.0022
	NM_004089
	NM_198057
FKBP5 (FKBP51)	NM_004116	46271_AT	4.6	0.0025	9.16	<0.001	10.8	<0.001	9.46	<0.001
FKBP5 (FKBP51)	NM_004116	34721_AT	2.15	0.177	5.71	0.0011	10	0.0003	12	<0.001
SERPINE1 (PAI-1)	NM_000602	672_AT	2.81	0.112	2.86	0.0237	9.41	0.0038	2.92	0.154
SERPINE1 (PAI-1)	NM_000602	38125_AT	1.54	0.126	1.96	0.0442	3.09	0.0047	3.3	0.0039
CDKN1C (p57KIP2)	NM_000076	39545_AT	1.3	0.369	4.56	0.0034	8.73	<0.001	7.97	<0.001
CDKN1C (p57KIP2)	NM_000076	1787_AT	1.28	0.418	4.02	0.0523	8.65	0.0026	5.73	0.0149
DUSP1 (MKP-1)	NM_004417	1005_AT	9.07	<0.001	4.91	<0.001	7.7	0.001	3.03	0.0047
SLC45A1 (DNB5)	XM_001129279	47478_AT	1.93	0.273	5.93	0.0257	6.11	0.0092	4.99	0.0304
	XM_937695
TSC22D3 (GILZ)	NM_001015881	36630_AT	3.94	0.0441	2.52	0.168	3.95	0.014	5.29	0.0082
	NM_004089
	NM_198057
ANPEP (Aminopeptidase N, CD13)	NM_001150	39385_AT	1.04	0.487	2.1	0.231	3.59	0.104	5.4	0.0094
CDKN1C (p57KIP2)	NM_000076	38673_S_AT	1.33	0.404	3.12	0.0999	3.68	0.0656	3.98	0.0529
MT1X (metallothionein 1X)	NM_005952	39120_AT	2.62	0.0148	2.62	0.0148	4.68	<0.001	4.68	<0.001
ZFP36 (TTP, TIS11)	NM_003407	40448_AT	3.5	0.0021	3.32	0.0032	3.06	0.0053	2.07	0.0331

SLC45A1, solute carrier family 45, member 1; TIS, TPA-inducible sequence.