Receptors | BzATP EC50 | nH | Maximum Currents | Cell No |
---|---|---|---|---|
μM | nA | |||
WT | 53 ± 4 | 1.9 ± 0.2 | 1.8 ± 0.4 | 9 |
H62A | 68 ± 9 | 2.1 ± 0.5 | 1.4 ± 0.2 | 10 |
H85A | 79 ± 6 | 1.6 ± 0.1 | 1.8 ± 0.6 | 6 |
H201A | 38 ± 3 | 1.9 ± 0.4 | 0.5 ± 0.1* | 8 |
H219A | 42 ± 7 | 1.9 ± 0.2 | 2.1 ± 0.5 | 6 |
H267A | 32 ± 2 | 2.4 ± 0.3 | 1.5 ± 0.3 | 4 |
E70A | 57 ± 8 | 2.7 ± 0.3 | 1.8 ± 0.3 | 4 |
K110A | 98 ± 7 | 4.4 ± 0.7 | 2.1 ± 0.6 | 5 |
E115A | 65 ± 15 | 2.2 ± 0.5 | 1.1 ± 0.1 | 5 |
K137A | 35 ± 4 | 2.4 ± 0.3 | 1.5 ± 0.3 | 4 |
K145A | 196 ± 11* | 3.5 ± 0.1 | 0.6 ± 0.1 | 6 |
D197A | 88 ± 7 | 2.7 ± 0.2 | 3.6 ± 0.7 | 7 |
E255A | 33 ± 10 | 1.8 ± 0.3 | 1.3 ± 0.2 | 4 |
H62A/D197A | 14 ± 1* | 2.1 ± 0.2 | 0.4 ± 0.1* | 6 |
↵* P < 0.01, compared with the wild-type receptor (WT).