TABLE 2

Quantification of the GABAA receptor α2 and α3 subunit immunoreactivity in forebrain-specific α1−/H and α1−/R mice compared with wild-type littermates (HfloxH/Emx1-cretg− and HfloxR/Emx1-cretg−)

Densitometry was performed in sections processed for immunoperoxidase staining (see Table 1). Values are expressed as percentage of wild-type control. Statistically significant differences in absolute values are indicated in bold (p < 0.05; Mann-Whitney U test).

Region
Forebrain-Specific, as a Proportion of OD α2
Forebrain-Specific, as a Proportion of OD α3
α1−/H
 α1−/R
 α1−/H
 α1−/R
% %
Parietal cortex, layer I-III 101 118 123 127
Parietal cortex, layer IV 129 129 115 142
Parietal cortex, layers V and VI 120 109 105 130
Frontal cortex, layers I-III 72 112 124 118
Frontal cortex, layers V and VI 56 112 140 134
CA1 80 97 122 106
CA3 84 88 148 109
Dentate gyrus 76 109 160 118
Subiculum 88 103 124 126
Striatum 95 114 156 120
Thalamic reticular nucleus 128 126
Cerebellum, molecular layer
127
126
126
125