TABLE 3

Plasma pharmacokinetic parameters after i.v. administration of 0.5 or 10 mg/kg midazolam to Cyp3a+/+ and Cyp3a−/− mice

Data are presented as mean ± S.D., n = 3-5.



Midazolam

1′-OH Midazolam

4-OH Midazolam

Cyp3a+/+
Cyp3a−/−
Cyp3a+/+
Cyp3a−/−
Cyp3a+/+
Cyp3a−/−
0.5 mg/kg
AUC(0-1.5h), hr · μg/l 29.5 ± 2.07 31.1 ± 4.03 29.7 ± 1.62 26.2 ± 3.25 0.95 ± 0.08 1.14 ± 0.09
Cl, l/h · kg 0.017 ± 0.001 0.016 ± 0.002
10 mg/kg
AUC(0-1.5h), hr · ug/l 842 ± 168 833 ± 111 1849 ± 234 1147 ± 199* 23.6 ± 5.1 15.8 ± 3.4
Cl, l/h · kg
0.012 ± 0.002
0.012 ± 0.002




  • AUC(0-1.5h), area under plasma concentration-time curve up to 1.5 h; Cl, plasma clearance.

  • * P < 0.05.