TABLE 1

Cell growth inhibitory and topoisomerase II inhibitory effects of the bisphenols

The relative resistance (RR) factors were calculated from the ratio of the IC50 value for the K/VP0.5 cell line divided by that for the K562 cell line or the DZR to the CHO cell line, respectively.

Compound or NSC No.
MTS Cell Growth Inhibition
MTT Cell Growth Inhibition
Topoisomerase IIα Inhibition, IC50
IC50
 RR
IC50
 RR
K562
K/VP0.5
CHO
DZR
μM μM μM
SCHO1 6.2 5.9 0.96 11 20 1.89 7.8
OCHO2 8.9 2.6 0.29 18 24 1.34 44
O3OH 9.3 15 1.61 13 14 1.04 0.74
DHDP 9.7 32 3.28 13 13 1.02 31
NSC38049 21 26 1.26 50 41 0.82 252
NSC58409 24 24 1.00 9.2 21 2.27 585
TDP 33 68 2.08 171 127 0.74 326
SCHO2 51 50 0.99 39 104 2.64 18
OCHO1 54 32 0.59 36 27 0.73 26
BispCP5 55 56 1.02 63 145 2.30 110
NSC402321 63 94 1.49 133 115 0.86 640
S4OH 64 26 0.41 10 8.6 0.83 0.69
Cyclofenil diphenol 71 66 0.93 64 83 1.30 511
BispAC3 72 79 1.10 77 90 1.17 201
EIBP 82 73 0.90 276 169 0.61 1640
Bisphenol A 96 122 1.27 124 187 1.51 501
4,4′-Dihydroxybenzophenone 99 146 1.47 171 194 1.13 483
NSC85582 117 73 0.63 218 151 0.69 571
BHPM 134 198 1.48 361 298 0.83 1011
DHDPS1 143 313 2.19 396 186 0.47 487
S3OH 143 223 1.56 61 42 0.69 133
DHDPS2 182 355 1.95 >1000 685 N.D. >1000
NSC40763
525
251
0.48
96
71
0.74
135

  • N.D., not determined.