Channel | Control | 1 mM NFA | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Vinact | k | Vinact | k | ΔVinact | n | |||||
mV | ||||||||||
hERG1 WT | −45.4 ± 2.6 | 24.2 ± 0.4 | −38.7 ± 2.9 | 24.4 ± 0.6 | 7.2 ± 0.6* | 15 | ||||
rERG2 WT | −62.8 ± 0.8 | 25.1 ± 0.4 | −57.5 ± 1.2 | 25.5 ± 0.3 | 5.3 ± 0.5 | 8 | ||||
rERG3 WT | −39.9 ± 2.8 | 24.3 ± 0.7 | −31.3 ± 2.5 | 23.9 ± 0.5 | 8.6 ± 1.3* | 7 | ||||
zERG WT | −61.5 ± 2.4 | 27.8 ± 0.6 | −53.2 ± 3.5 | 28.4 ± 0.7 | 8.3 ± 0.3** | 7 | ||||
N-S4 | −42.6 ± 3.3 | 23.7 ± 0.6 | −35.1 ± 3.6 | 23.5 ± 0.6 | 7.5 ± 0.4** | 6 | ||||
S1-S4 | −44.0 ± 4.8 | 25.8 ± 0.8 | −35.5 ± 7.1 | 24.6 ± 0.8 | 8.5 ± 2.6 | 6 | ||||
L12 | −48.7 ± 2.2 | 25.8 ± 0.7 | −42.2 ± 1.6 | 25.9 ± 0.7 | 6.5 ± 3.0 | 6 | ||||
S2 | −46.6 ± 3.6 | 23.8 ± 0.8 | −36.7 ± 4.0 | 24.9 ± 1.4 | 9.9 ± 0.5** | 5 | ||||
L23 | −55.3 ± 1.8 | 24.5 ± 0.1 | −47.9 ± 1.4 | 24.9 ± 0.1 | 7.3 ± 1.0 | 3 | ||||
L34 | −49.8 ± 3.6 | 27.1 ± 0.5 | −42.6 ± 2.9 | 27.2 ± 0.7 | 7.2 ± 1.1 | 8 | ||||
hERG1 G514R | −37.8 ± 4.2 | 24.9 ± 0.5 | −28.8 ± 4.8 | 25.1 ± 0.6 | 9.0 ± 0.8** | 9 | ||||
hERG1 TTT | −50.0 ± 2.1 | 25.9 ± 0.4 | −40.9 ± 3.3 | 25.6 ± 0.8 | 9.1 ± 1.4** | 3 | ||||
rERG3 G513R | −39.1 ± 4.7 | 25.2 ± 0.6 | −31.2 ± 4.7 | 25.7 ± 0.8 | 8.0 ± 1.2* | 5 |