Potencies of various agonists at the group III mGluRs as assessed using the GIRK thallium flux assay
Potencies of compounds are shown in micromolar concentrations for EC50 values.
Agonist | mGluR4 | mGluR7 | mGluR8 |
|---|---|---|---|
| Glutamate | 17.8 ± 3.0 | 1289 ± 328 | 7.0 ± 1.9 |
| L-AP4 | 0.20 ± 0.03 | 219 ± 19 | 0.13 ± 0.02 |
| DCPG | 3.6 ± 0.5 | 350 ± 189 | 0.08 ± 0.01 |