Css (nM)a | 382 ± 46 | 214 ± 11** |
CLtot,plasma (ml/min/kg b.wt.) | 33.6 ± 3.8 | 56.1 ± 3.1** |
CLbile,plasma (ml/min/kg b.wt.) | 9.32 ± 1.01 | 25.9 ± 1.1** |
CLbile,liver (ml/min/kg b.wt.) | 0.235 ± 0.025 | 0.495 ± 0.023** |
Vbile (nmol/min/kg b.wt.) | 3.17 ± 0.27 | 5.64 ± 0.19** |
Bile flow rate (μl/min/kg b.wt.) | 53.7 ± 3.4 | 88.6 ± 7.4* |
K
p,liver
| 37.9 ± 3.4 | 48.0 ± 2.1* |
CLurine,p (ml/min/kg b.wt.) | 14.2 ± 2.3 | 19.0 ± 1.8 |
Vurine (nmol/min/kg b.wt.) | 4.84 ± 0.91 | 4.11 ± 0.30 |
GFR (ml/min/kg b.wt.) | 15.1 ± 2.1 | 19.9 ± 1.8 |
K
p,kidney
| 23.5 ± 2.3 | 24.8 ± 2.1 |
K
p,brain
| 0.0169 ± 0.0016 | 0.0171 ± 0.0021 |