Parameters | FVB Mice | Mrp3−/− Mice |
---|---|---|
mRNA expression level normalized by the expression level of mGAPDH | ||
mOatp1a1 | 5.20 ± 0.63 | 5.66 ± 0.34 |
mOatp1a4 | 1.44 ± 0.17 | 1.42 ± 0.20 |
mOatp1b2 | 4.35 ± 0.12 | 3.02 ± 0.43* |
mMrp3 | 1.03 ± 0.21 | N.D. |
mMrp4 | 0.0460 ± 0.0243 | 0.0255 ± 0.0032 |
mMrp2 | 18.8 ± 2.2 | 17.8 ± 1.73 |
mMdr1a | 0.431 ± 0.064 | 0.231 ± 0.006 |
mMdr1b | 0.319 ± 0.061 | 0.356 ± 0.117 |
mBcrp | 0.610 ± 0.064 | 0.796 ± 0.018* |
mBsep | 11.3 ± 1.5 | 10.7 ± 1.1 |
mMate1 | 0.779 ± 0.038 | 0.620 ± 0.042* |
Bile flow rate (μl/min/kg) | 51.9 ± 8.6 | 81.1 ± 3.5* |
Hepatic GSH concentration (mM) | 4.27 ± 0.75 | 5.62 ± 0.13 |
GSH excretion rate (nmol/min/kg) | 231 ± 37 | 300 ± 54 |
GSH efflux clearance (μl/min/kg) | 54.8 ± 3.3 | 53.3 ± 9.1 |
Total bile acids excretion rate (μmol/min/kg) | 4.21 ± 0.64 | 3.81 ± 0.28 |
Total bile acids efflux clearance (μl/min/kg) | 498 ± 67 | 486 ± 28 |
N.D., not detected.
↵* p < 0.05.