TABLE 1

Effect of IL-13 on KCl- and CCh-induced contractions in isolated murine tracheal rings

Tissues isolated from CD1 mice and were incubated with media alone (controls, n = 24) or IL-13 (10 and 100 ng/ml, n = 12 per group) for 24 h before assessment of contractile responses to KCl or CCh. Values are mean ± S.E.M. of E_max or pEC₅₀ values.

	KCl		CCh
	E_max	pEC₅₀	E_max	pEC₅₀
	mN/mg tissue	-log[M]	mN/mg tissue	-log[M]
Control	1.2 ± 0.1	1.43 ± 0.03	2.0 ± 0.2	6.53 ± 0.09
IL-13 (10 ng/ml)	2.2 ± 0.3^a	1.44 ± 0.03	3.8 ± 0.5^a	6.54 ± 0.10
IL-13 (100 ng/ml)	2.7 ± 0.4^a	1.44 ± 0.03	3.8 ± 0.5^a	6.53 ± 0.09

↵ a P < 0.01 compared with matched control segments.