Acetylcholine | Imidacloprid | Desnitro-Imidacloprid | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Imax | pEC50 | Hill | n | Imax | pEC50 | Hill | n | Imax | pEC50 | Hill | n | ||||||||||
Wild type | 1.03 ± 0.04 | 3.91 ± 0.05 | 1.4 ± 0.2 | 5 | 0.49 ± 0.03 | 3.63 ± 0.07 | 1.6 ± 0.4 | 6 | 1.21 ± 0.05 | 5.14 ± 0.07 | 1.2 ± 0.2 | 4 | |||||||||
L118D | 1.07 ± 0.04 | 2.78 ± 0.04* | 1.3 ± 0.2 | 4 | N.D. | N.D. | N.D. | 4 | 1.24 ± 0.11 | 4.21 ± 0.11* | 1.5 ± 0.5 | 4 | |||||||||
L118E | 0.97 ± 0.02 | 3.12 ± 0.03* | 1.7 ± 0.2 | 7 | N.D. | N.D. | N.D. | 5 | 1.37 ± 0.06 | 4.28 ± 0.08* | 1.6 ± 0.3 | 5 | |||||||||
L118K | N.D. | N.D. | N.D. | 4 | 1.14 ± 0.10 | 2.94 ± 0.05* | 2.1 ± 0.4 | 4 | N.D. | N.D. | N.D. | 4 | |||||||||
L118R | N.D. | N.D. | N.D. | 5 | 1.07 ± 0.05 | 3.00 ± 0.02* | 2.4 ± 0.4 | 5 | N.D. | N.D. | N.D. | 4 |
N.D., not determined because the response to agonists were not detected or very small.
↵* p < 0.01