hNK3R | RO4908594 | ||||
---|---|---|---|---|---|
Ki | Ki (Mutant)/Ki (WT) | nH | |||
nM | |||||
WT | 1.6 ± 0.1 | 1.1 ± 0.1 | |||
V95A | 1.6 ± 0.4 | 1.0 | 0.9 ± 0.1 | ||
V95L | 3.5 ± 0.1 | 2.2 | 1.0 ± 0.0 | ||
V95I/A99S | 4.2 ± 0.8 | 2.6 | 1.1 ± 0.1 | ||
N138A | 4.0 ± 0.7 | 2.5 | 1.2 ± 0.0 | ||
T139A | 2.9 ± 0.5 | 1.8 | 1.0 ± 0.1 | ||
V95L/T139A | 4.9 ± 0.5 | 3.1 | 1.1 ± 0.0 | ||
L232A | 1.6 ± 0.2 | 1.0 | 1.1 ± 0.0 | ||
Y315F | 0.6 ± 0.04 | 0.4 * | 1.6 ± 0.1 | ||
S341A | 2.0 ± 0.2 | 1.3 | 1.3 ± 0.3 | ||
F342A | 0.02 ± 0.0 | 0.01 *** | 0.8 ± 0.2 | ||
M346A | 6.0 ± 0.3 | 3.8 ** | 1.1 ± 0.1 | ||
S348A |
8.0 ± 0.1
|
5.0
***
| 1.1 ± 0.1 |