TABLE 2
In silico similarity search results of scaffolds related to SID7969543 and SID7970631
Inhibition was measured at 10 μM, n = 1. Compounds showing percentage inhibition greater than the calculated hit-cutoff (47.96%) were considered active.
 | ||||
|---|---|---|---|---|
| Compound | R1 | R2 | SF-1 Inhibition | |
| % | ||||
| SID7970631 | −CH3 |
| 83.1 | |
| SID7969543 | −CH3 |
| 81.8 | |
| SID7970257 | −CH3 |
| 17.6 | |
| SID7969723 | −CH3 |
| 8.4 | |
| SID7970398 | −CH3 |
| −0.2 | |
| SID7971227 | −H |
| 30.6 | |
| SID7970995 | −H |
| 10.8 | |
| SID7970701 | −H |
| −12.3 | |