TABLE 1

Summary of the short-term and long-term effects of HDAC inhibitors on proinflammatory transcription factors and genes in IL-1β-stimulated myometrial cells

	Short-Term Effects	Long-Term Effects
Transcription factors
NF-κB	Increased nuclear localization, DNA binding, and transcriptional activity	Decreased DNA binding
c-Jun	Decreased expression and nuclear levels	Decreased expression and nuclear levels
IKBA gene	Increased expression	No effect
Proinflammatory genes
COX-2	Decreased expression	Decreased expression
IL-8	Decreased expression	Decreased expression
IL-6	Decreased expression	Decreased expression
RANTES	Decreased expression	Decreased expression