mENT1 | mENT1Δ11 | |||||
---|---|---|---|---|---|---|
Control | NEM | Control | NEM | |||
NBMPR binding | ||||||
Kd1 (nM) | 0.15 ± 0.01 | 0.53 ± 0.15* | 0.021 ± 0.005 | 0.025 ± 0.008 | ||
Kd2 (nM) | 1.9 ± 0.9 | 0.61 ± 0.07* | ||||
Bmax1 (sites/cell × 103) | 517 ± 111 | 725 ± 128* | 134 ± 40 | 55 ± 20* | ||
Bmax2 (sites/cell × 103) | 546 ± 146 | 602 ± 133 | ||||
2-Chloroadenosine uptake | ||||||
Km (μM) | 44 ± 19 | 95 ± 34* | 43 ± 11 | 55 ± 16 | ||
Vmax (pmol/μl/s) | 17 ± 4 | 27 ± 4* | 19 ± 3 | 18 ± 4 |
↵* Significant difference from the respective control (Student's t test for paired samples, P < 0.05).