TABLE 2

Selectivity indexes of SID 26681509 against papain and human cathepsins B, G, K, L, S, and V.


Enzyme

Selectivity Index
10 min
30 min
60 min
90 min
Cathepsin L, human liver 1 1 1 1
Cathepsin V, human, recombinant, NSO cells 7 9 11 11
Cathepsin S, human spleen 7 10 13 14
Papain, C. papaya 44 40 46 31
Cathepsin B, human liver 48 40 45 50
Cathepsin K, human, recombinant, E. coli 114 113 151 137
Cathepsin G, human neutrophil