Liver-to-plasma ratio comparing wild-type and Slco1b2(−/−) animals after a single intravenous dose of rifampin (1 mg/kg)
Data are expressed as mean liver-to-plasma ratio (mean ± S.D.).
Time | Wild-Type | Slco1b2(−/−) |
|---|---|---|
| 5 min | 2.0 ± 1.2 | 0.6 ± 0.3* |
| 15 min | 5.8 ± 2.9 | 1.6 ± 1.0* |
| 30 min | 11.9 ± 6.7 | 2.4 ± 2.4* |
| 1 h | 18.0 ± 16.6 | 3.0 ± 2.2 |
| 4 h | 4.7 ± 1.3 | 3.0 ± 0.4* |
↵* P < 0.05.