Antiviral activity of CBAs and polyanions against wild-type and mutant HHA-resistant, UDA-resistant, and PRM-A-resistant SIVmac251 strains
Virus Strain | EC50 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HHA | GNA | UDA | PRM-A | DS5000 | PVAS | ||||||
| μM | |||||||||||
| SIVmac251 | 0.002 ± 0.000 | 0.006 ± 0.002 | 0.036 ± 0.004 | 2.3 ± 0.06 | 0.38 ± 0.22 | 0.020 ± 0.011 | |||||
| SIV/UDA(1) | 0.013 ± 0.008 | 0.013 ± 0.005 | 0.25 ± 0.13 | 9.7 ± 2.4 | 0.25 ± 0.13 | 0.017 ± 0.012 | |||||
| SIV/PRM-A(1) | 0.034 ± 0.010 | 0.027 ± 0.012 | 0.32 ± 0.08 | 11 ± 0.4 | 0.35 ± 0.06 | 0.017 ± 0.003 | |||||
| SIV/HHA(1) | 0.024 ± 0.012 | 0.030 ± 0.003 | 0.21 ± 0.04 | 12 ± 1.5 | 0.36 ± 0.04 | 0.017 ± 0.002 | |||||