TABLE 1

CXCL8 synergizes with CCL7 in peripheral blood monocyte migration

CCL7 (3, 10, and 30 ng/ml) was combined with buffer or 50 ng/ml CXCL8 in the lower compartment of the Boyden microchamber to measure monocyte chemotaxis. The chemotactic response is expressed as the CI ± S.E.M., derived from four to eight independent experiments. For statistical analysis, see Materials and Methods.


Chemokine

CI

P Value
Buffer +
3 ng/ml CCL7 2.7 ± 1.4
10 ng/ml CCL7 5.4 ± 1.6
30 ng/ml CCL7 19.3 ± 8.8
50 ng/ml CXCL8 +
0 ng/ml CCL7 4.3 ± 0.3
3 ng/ml CCL7 13.2 ± 2.1 0.02
10 ng/ml CCL7 13.7 ± 1.1 0.02
30 ng/ml CCL7
27.6 ± 5.6
0.38