Enzyme kinetic parameter estimates obtained for hyodeoxycholic acid glucuronidation by human UGT2A3 variants (UGT2A3.1 and UGT2A3.2) expressed in SF21 insect cells
| UGT2A3.1 | UGT2A3.2 | |||
|---|---|---|---|---|
| Estimate | S.E. | Estimate | S.E. | |
| Vmax (pmol/min/mg) | 27 | 2 | 20 | 2 |
| Km (μM) | 69 | 7 | 44 | 12 |
| Vmax/Km (ml/min/g) | 0.40 | 0.04 | 0.46 | 0.13 |