Summary pIC50 values for [125I]rAmy binding at human mycRAMP1 mutants containing individual RAMP3 residues expressed with HA-CT(a)
**p < 0.01, ***p < 0.001 versus WT AMY1(a) by one-way ANOVA followed by Dunnett's test. Data are mean ± S.E.M. of three independent experiments, each performed in duplicate.
Receptor | pIC50 |
|---|---|
| CT(a) | 7.13 ± 0.16 |
| WT AMY1(a) | 8.19 ± 0.03 |
| W74E AMY1(a) | 8.19 ± 0.05 |
| E88L AMY1(a) | 8.01 ± 0.04 |
| V89A AMY1(a) | 7.67 ± 0.09** |
| F93I AMY1(a) | 7.37 ± 0.16*** |