Inhibitory effect of everolimus alone or in association with fluvastatin on cell proliferation
| Inhibition (Conc.) for Fluvastatin | IC50 | Maximal Effect (Conc.) | ||||
|---|---|---|---|---|---|---|
| Assay | Everolimus | Everolimus + Fluvastatin | Ratio | Everolimus | Everolimus + Fluvastatin | |
| nM | ||||||
| Cell proliferation | −9.2 ± 8.4% (0.5 μM) | 2.5 | 1.0 | 2.5 | −54.9 ± 12.9% (0.5 μM) | −72.4 ± 8.3% (0.5 μM) |
| Thymidine incorporation | −14.2 ± 9.1% (2 μM) | 6.5 | 0.19 | 34.2 | −63.3 ± 4.6% (0.1 μM) | −75.9 ± 2.4% (0.1 μM) |
| Cell cycle (S phase) | 3.2 ± 23.8% (2 μM) | −76.9 ± 3.8% (0.1 μM) | −83.4 ± 1.5% (0.1 μM) | |||