TABLE 2

Effects of the modulators on the ACh sensitivity of the α7 wild-type receptor and the chimeras

Receptor Type	CT			10 μM NS-1738			1 μM PNU-120596
Receptor Type		EC₅₀	n_H	EC₅₀	n_H	EC₅₀	n_H
	μM		μM		μM
α7	146 ± 11	1.7 ± 0.06	34 ± 7	2.06 ± 0.35	50 ± 9	1.2 ± 0.1
	n = 5		n = 5		n = 4
I	74 ± 6.5	1.35 ± 0.14	17 ± 3	1.5 ± 0.08	64.7 ± 6.8	1.2 ± 0.1
	n = 5		n = 5		n = 3
II	22 ± 1.6	1 ± 0.04	1 ± 0.37	0.67 ± 0.08	18.8 ± 6.8	0.94 ± 0.02
	n = 4		n = 4		n = 4
III	31 ± 12	1.2 ± 0.17	4.8 ± 2.4	0.67 ± 0.08	25.8 ± 8.1	1.1 ± 0.08
	n = 4		n = 5		n = 4
IV	86 ± 16	1.45 ± 0.1	15 ± 2	0.67 ± 0.08	70 ± 31	1.53 ± 0.13
	n = 6		n = 6		n = 3
V	19 ± 3	1.48 ± 0.04	1.9 ± 1	1.24 ± 0.04	23.5 ± 2.5	0.95 ± 0.1
	n = 8		n = 7		n = 4
VI	16.5 ± 3.4	0.83 ± 0.12	0.97 ± 0.1	0.94 ± 0.07	29 ± 8.7	1.16 ± 0.29
	n = 8		n = 8		n = 2
VII	112 ± 8.5	1.4 ± 0.02	13.9 ± 0.63	1.59 ± 0.06	96 ± 8.7	1.31 ± 0.01
	n = 7		n = 7		n = 3