Compound | Wild Type | I3-N | I3-M | I3-C | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Ki | 95% CI | Ki | 95% CI | Ki | 95% CI | Ki | 95% CI | |||||
μM | μM | μM | μM | |||||||||
NE | 15.6 | 10.5-23.1 | 18.9 | 14.5-24.7 | 15.5 | 12.4-19.2 | 31.2 | 29.9-32.6 | ||||
DA | 47.5 | 45.1-50.1 | 52.4 | 36.8-74.7 | 35.7 | 28.8-44.3 | 55.9 | 42.1-74.4 | ||||
CL | 0.10 | 0.08-0.13 | 0.15 | 0.14-0.17 | 0.12 | 0.10-0.14 | 0.24 | 0.18-0.32 | ||||
OC | 41.1 | 34.5-48.8 | 65.8 | 43.5-96.1 | 93.6 | 69.0-126.9 | 70.4 | 65.7-75.4 | ||||
NF | 30.4 | 17.0-54.2 | 40.3 | 33.7-48.3 | 50.3 | 20.0-126.5 | 52.3 | 29.1-94.1 | ||||
[3H]RX821002 (nM) | 3.59 | N.D. | 2.58 | N.D. | 4.38 | N.D. | 3.80 | N.D. |
CI, confidence interval; N.D., not determined.