TABLE 1

Antiviral effects (pIC50) of CCR5 modulators

HOS S.E.M. values calculated based on a pooled estimate of residual standard deviation = 0.2999. PBMC S.E.M. values calculated based on a pooled estimate of residual standard deviation = 0.5850.

Compound
N
Mean
S.D.
S.E.M.
HOS
    Aplaviroc 270 8.79 0.277 0.018
    TAK652 5 9.39 0.184 0.13
    Maraviroc 33 8.98 0.231 0.05
    TAK779 77 7.9 0.444 0.062
    Vicriviroc 47 8.67 0.207 0.042
    Sch-C 159 8.17 0.318 0.023
PBMC
    Aplaviroc 306 8.8 0.566 0.033
    TAK652 19 9.42 0.519 0.134
    Maraviroc 108 8.72 0.558 0.056
    TAK779 36 7.01 0.544 0.098
    Vicriviroc 42 8.19 0.637 0.09
    Sch-C
65
7.51
0.711
0.073