Fatty acid composition in the livers of bezafibrate-treated wild-type (+/+) and Ppara-null (−/−) mice
Results are expressed as mean ± S.D. (n = 6 in each group).
Bezafibrate | Ppara(+/+) | Ppara(−/−) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 mg/kg/day | 10 mg/kg/day | 100 mg/kg/day | 0 mg/kg/day | 10 mg/kg/day | 100 mg/kg/day | |||||
| C12:0 | 0.2 ± 0.0 | 0.2 ± 0.0 | 0.2 ± 0.0 | 0.2 ± 0.0 | 0.2 ± 0.0 | 0.1 ± 0.0 | ||||
| C14:0 | 0.8 ± 0.0 | 0.7 ± 0.1 | 0.7 ± 0.0 | 0.7 ± 0.0 | 0.6 ± 0.0 | 0.6 ± 0.2 | ||||
| C14:1 n-5 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | ||||
| C16:0 | 27.6 ± 2.0 | 29.2 ± 4.0 | 28.0 ± 0.1 | 20.9 ± 0.3 | 23.6 ± 4.0 | 20.8 ± 0.2 | ||||
| C16:1 n-7 | 2.5 ± 0.4 | 2.0 ± 0.5 | 3.4 ± 1.1 | 2.0 ± 0.2 | 1.6 ± 0.1 | 2.0 ± 0.8 | ||||
| C18:0 | 12.6 ± 0.4 | 12.5 ± 2.0 | 11.1 ± 1.1 | 12.8 ± 0.3 | 14.0 ± 1.5 | 8.5 ± 0.3* | ||||
| C18:1 n-9 | 11.9 ± 0.4 | 10.5 ± 3.4 | 15.6 ± 1.1* | 13.9 ± 0.3 | 11.0 ± 3.0 | 18.4 ± 3.5 | ||||
| C18:2 n-6 | 21.9 ± 0.4 | 23.3 ± 3.7 | 15.9 ± 0.3* | 25.8 ± 0.3 | 25.8 ± 1.8 | 27.6 ± 3.5 | ||||
| C18:3 n-6 | 0.2 ± 0.0 | 0.2 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.2 ± 0.0* | ||||
| C18:3 n-3 | 1.0 ± 0.1 | 0.7 ± 0.2 | 0.3 ± 0.1* | 1.4 ± 0.2 | 0.7 ± 0.2 | 0.9 ± 0.1 | ||||
| C20:0 | 0.5 ± 0.2 | 0.4 ± 0.1 | 0.2 ± 0.0 | 0.7 ± 0.0 | 0.5 ± 0.2 | 0.5 ± 0.0 | ||||
| C20:1 n-9 | 0.7 ± 0.1 | 0.7 ± 0.4 | 0.6 ± 0.0 | 1.1 ± 0.0 | 0.9 ± 0.3 | 1.4 ± 0.2 | ||||
| C20:2 n-6 | 0.5 ± 0.0 | 0.5 ± 0.1 | 0.4 ± 0.0* | 0.8 ± 0.1 | 0.7 ± 0.1 | 0.9 ± 0.1 | ||||
| C20:3 n-9 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.3 ± 0.1* | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | ||||
| C20:3 n-6 | 2.0 ± 0.1 | 2.0 ± 0.1 | 4.0 ± 0.1* | 1.6 ± 0.1 | 1.4 ± 0.1 | 1.4 ± 0.0 | ||||
| C20:4 n-6 | 6.2 ± 0.4 | 6.5 ± 0.5 | 7.4 ± 0.8 | 5.6 ± 0.1 | 6.7 ± 0.7 | 5.2 ± 0.4 | ||||
| C20:5 n-3 | 0.8 ± 0.2 | 0.8 ± 0.3 | 1.2 ± 0.3 | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.0 ± 0.3 | ||||
| C22:0 | 0.1 ± 0.1 | 0.1 ± 0.0 | 0.0 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | ||||
| C22:1 n-9 | 0.2 ± 0.1 | 0.2 ± 0.0 | 0.1 ± 0.0 | 0.2 ± 0.0 | 0.2 ± 0.0 | 0.3 ± 0.1 | ||||
| C22:4 n-6 | 0.2 ± 0.0 | 0.3 ± 0.1 | 0.3 ± 0.0 | 0.3 ± 0.0 | 0.4 ± 0.1 | 0.6 ± 0.1* | ||||
| C22:5 n-3 | 0.7 ± 0.2 | 0.7 ± 0.0 | 1.0 ± 0.2 | 1.1 ± 0.0 | 1.1 ± 0.2 | 1.2 ± 0.3 | ||||
| C22:6 n-3 | 9.0 ± 0.7 | 8.5 ± 1.9 | 9.1 ± 0.1 | 9.3 ± 0.2 | 8.9 ± 0.2 | 8.1 ± 0.3* | ||||
| C24:0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.1 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | ||||
| C24:1 n-9 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | ||||
↵* P < 0.05, between treated and untreated mice of the same genotype.