Compound | IC50 | ||||||
---|---|---|---|---|---|---|---|
TK-1 | TK-2 | HSV-1 TK | VZV TK | ||||
μM | |||||||
1 | >500 | 1.2 ± 0.1 | 444 ± 18 | 37 ± 2.0 | |||
2 | >500 | 3.1 ± 0.3 | ≥500 | 77 ± 51 | |||
3 | >500 | 1.2 ± 1.1 | 400 ± 54 | 31 ± 5.0 | |||
4 | ≥500 | 0.43 ± 0.04 | 232 ± 39 | 28 ± 1.0 | |||
5 | ≥500 | 0.47 ± 0.04 | 46 ± 4.0 | 21 ± 5.0 | |||
6 | ≥500 | 0.64 ± 0.31 | 87 ± 36 | 15 ± 1.0 | |||
7 | 316 ± 1.2 | 0.15 ± 0.01 | 195 ± 54 | 24 ± 3.0 | |||
8 | 416 ± 6.0 | 0.42 ± 0.0 | 335 ± 25 | 5.6 ± 0.8 | |||
9 (α-dThd) | 99 ± 51 | 46 ± 2.0 | 34 ± 3.0 | 47 ± 3.0 | |||
10 | >500 | 57 ± 20 | 422 ± 6.0 | 30 ± 7.0 | |||
11 | >500 | 405 ± 78 | >500 | 40 ± 3.0 | |||
12 | >500 | 41 ± 3.0 | 365 ± 22 | 45 ± 6.0 | |||
13 | >500 | 38 ± 1.0 | 472 ± 40 | 40 ± 4.0 | |||
14 | >500 | 110 ± 13 | >500 | 95 ± 66 | |||
15 | >500 | 99 ± 36 | >500 | 150 ± 38 | |||
16
| >500 | 31 ± 6.0 | 392 ± 8.0 | 45 ± 1.0 |