Apparent therapeutic benefits of small molecule antagonists of phosphatase complexes
Protein Complex | Protein Complex Antagonists | Consequence of Disrupted Complex | Apparent Therapeutic Value |
|---|---|---|---|
| PP1-GADD34 (Boyce et al., 2005) | Salubrinal | ↑ eIF2α phosphorylation | ↓ HSV replication |
| PP1-HDAC 1/6 (Chen et al., 2005) | Trichostatin A | ↓ Akt activity | ↓ Cell growth and transformation |
| PP2B-NFAT (Clipstone and Crabtree, 1992) | FK506, Cyclosporin A | ↓ PP2B activity | Immunosuppression |
| PP2A-Akt-βArr2 (Beaulieu et al., 2008) | Lithium | ↑ Akt activity | Mood stabilizer |