TABLE 1

TRPV1 agonists


Group

Compound

Compound Number

EC50

Species

Reference
M
Endogenous agonists (fatty acids) Anandamide 2a 10−5 Rat Ahern (2003)
NADA 3a 10−8-10−7 Human and rat Huang et al. (2002)
12S-HPETE 5a 10−5 Human and rat Hwang et al. (2000)
Exogenous agonists of natural, semisynthetic and synthetic origin Capsaicin 1 10−8-10−6 Rodent Caterina et al. (1997)
Piperine 8 10−5-10−4 Human Liu and Simon (1996)
Eugenol 9 10−3-10−2 Human Yang et al. (2003)
Resiniferatoxin 11a 10−10-10−8 Rat Szallasi and Blumberg (1989)
Olvanil 12a 10−10-10−9 Human Appendino et al. (2005b)
Phar 12b 10−11-10−10 Human Appendino et al. (2005b)

Camphor
13
10−3-10−2
Rat
Xu et al. (2005)