TRPV1 antagonists
Group | Compound | Compound Number | IC50 | Species | Reference |
|---|---|---|---|---|---|
| M | |||||
| Naturally occurring | Thapsigargin | 23 | 10−6-10−5 | Rat | Tóth et al. (2002) |
| Yohimbine | 24 | 10−5-10−4 | Rat | Dessaint et al. (2004) | |
| 1,3-Di(arylalkyl)thioureas | Capsazepine | 22 | 10−7-10−6 | Rodent | Caterina et al. (1997) |
| Compound | 26 | 10−5 | Rat | Lee et al. (2003) | |
| JYL1421 | 27 | 10−8 | Rat | Wang et al. (2002) | |
| Iodinatede vanillyl derivatives | 5-iodoRTX | 11b | 10−9 | Rat | Wahl et al. (2001) |
| Di(arylalkyl)- and aryl(arylakyl)ureas | BCTC | 28 | 10−9 | Rat | Pomonis et al. (2003) |
| A-425619 | 29a | 10−9 | Rat | McDonald et al. (2008) | |
| SB-452533 | 31 | 10−8-10−7 | Human | Rami et al. (2004) | |
| ABT-102 | 32 | 10−9 | Human | Surowy et al. (2008) | |
| Cinnamides | SB-366791 | 33 | 10−9 | Human & rat | Patwardhan et al. (2006) |
| AMG-9810 | 34 | 10−8 | Human & rat | Doherty et al. (2005) | |
| Carboxamides | SB-782443 | 36 | 10−8-10−7 | Human & rat | Westaway et al. (2008b) |
| Compound | 38 | 10−8-10−7 | Human & rat | Westaway et al. (2008b) | |
| Nonclassic antagonists | |||||
| Imidazole derivatives | Compound | 39 | 10−9 | Rat | Gore et al. (2007) |
| AMG517 | 40 | 10−10 | Rat | Gavva et al. (2007) | |
| Noncompetitive | Ruthenium Red | 10−7 | Rat | García-Martínez et al. (2000) | |
| AG 489 | 41a | 10−8 | Rat | Kitaguchi and Swartz (2005) | |
|
| DD161515 |
43
| 10−7-10−6 | Rat | García-Martínez et al. (2002) |