TABLE 5

TRPV4 activators


Group

Compound

Compound Number

EC50

Species

Reference
M
Activators Arachidonic Acid 10−5 Mouse Watanabe et al. (2003)
5,6-EET 10−6 Mouse Watanabe et al. (2003)
BAA 55 10−7-10−6 Mouse Smith et al. (2006)
4α-PDD 56a 10−6 Mouse Watanabe et al. (2002)

GSK10116790A
57
10−9-10−8
Human and mouse
Thorneloe et al. (2008)