TABLE 6

List of conserved residues in four chemokine receptors that have been mutated to alanine in this and other published studies (Dragic et al., 2000; Mirzadegan et al., 2000; Berkhout et al., 2003; de Mendonça et al., 2005; Maeda et al., 2006; Seibert et al., 2006; Wise et al., 2007)

Mutation of the underlined and bold residues has been reported to display a loss of antagonist activity. Residues in parentheses have no significant effect on either agonist or antagonist activity; italic residues indicate mutants with poor cell surface expression and/or reduced chemotactic activity compared with wild-type receptor; residues in normal type and not in parentheses have not been mutated; and underlined and italic residues have significant effect on small molecule agonist activity. Glu7.39 mutation results are for E7.39Q mutation and not the alanine mutation.