TABLE 1

Correlation of CYP4F2 levels with VK1 oxidase activity in genotyped HLM

Numbers in parentheses denote standard deviations.

HLM Pool Genotype (rs2108622)
CYP4F2 Contenta
VK1 Met. Formationb
VK1 Met. Formationc
pmol/mg protein pmol/min/mg pmol/min/nmol
CC 11.3 0.85 (0.13) 75 (11)
CT 7.2 0.44 (0.01) 61 (1.1)
TT
2.5
0.21 (0.02)
84 (6.7)

  • ↵ a Values determined by Western blot analysis.

  • ↵ b VK1 oxidase activities normalized to total microsomal protein.

  • ↵ c VK1 oxidase activities normalized to CYP4F2 content.