The effects of ivermectin resistance-associated mutations on the ability of glutamate to activate H. contortus GluClα3B channels
All values are given as the mean ± S.E.M.
Mutation | EC50 for l-Glutamate | Hill Number | Number of Measurements |
|---|---|---|---|
| μM | |||
| Wild type | 27.6 ± 2.7 | 1.89 ± 0.35 | 7 |
| E114G | 31.5 ± 3.2 | 1.48 ± 0.31 | 6 |
| V235A | 26.2 ± 2.5 | 1.97 ± 0.35 | 6 |
| L256F | 92.2 ± 3.5*** | 1.09 ± 0.16** | 8 |
| T300S | No channels |
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