TABLE 2

Spermostatic activity in seminal plasma

Bold numbers correspond to compound numbers in Supplemental Table 1. Spermostatic activity was measured in the Sander Kramer assay at two doses.

		Spermostatic^a
Compound No.	Compound	50 μM	100 μM
22	2,3,7-Trichloro-5-hydroxy-p-naphthoquinone	−	+
24	2,3-Dichloro-p-naphthoquinone	+	+
6	2,5-Dichloro-p-benzoquinone	−	−
35	Bismaleimide	+	+
9	p-Chloranil	−	−
10	2-Chloro-p-benzoquinone	−	−
38	Quinhydrone	+	+
27	2,2′-Bis(p-naphthoquinone)	+	+
71	p-Naphthohydroquinone	+	+
11	p-Benzoquinone	+/−	+/−
19	p-Naphthoquinone	+	+
31	o-Naphthoquinone	−	−
20	Juglone	−	+
46	Hydroquinone^a	+	+
39	N9^b	−	−

↵ a This compound was weakly active in the absence of seminal plasma with an ED₅₀ value of >500 μM.
↵ b N9 is the current industrial standard and is included for comparative purposes. In the presence of seminal plasma, the ED₅₀ value for N9 was 150 μM.