KLYP956 isoform and species selectivity profile
Values in second, third, and fourth column represent IC50 ± S.D. for NOS inhibition. Calculations are averages of at least three experiments.
Species | iNOS | nNOS | eNOS | Selectivity | ||
|---|---|---|---|---|---|---|
| i/n | i/e | |||||
| μM | -fold | |||||
| Human | 0.01 ± 0.01 | 2.6 ± 1.0 | 19 ± 6.5 | 260 | 1900 | |
| Murine | 0.14 ± 0.12 | 0.15 ± 0.05 | 12.0 ± 4.8 | Non-selective | 86 | |
i/n, iNOS/nNOS; i/e, iNOS/eNOS.