Effect of TC22-siRNA on gene level changes related to carcinogenesis
Gene | Description | Change | |
|---|---|---|---|
| -fold | |||
| Apoptosis signaling | TNFRSF10B | TNF receptor superfamily containing intracellular death domain that transduces apoptosis. | +3.1 |
| TNFRSF25 | TNF receptor superfamily, possibly involved in regulating lymphocyte homeostasis. Stimulates nuclear factor-κB activity and regulates cell apoptosis. | +2.0 | |
| Cell adhesion | ITGA1 | Integrin, α1 | +2.6 |
| ITGA3 | Integrin, α3 (CD49C) | +3.0 | |
| Angiogenesis | IGF1 | Insulin-like growth factor 1/somatomedin C | +6.9 |
| TEK | TEK tyrosine kinase (related to TIE family) found in endothelial cells interacts with angiopoietin-1 to mediate endothelial cell-smooth muscle cell communication in venous morphogenesis. | +12.7 | |
| VEGFA | Vascular endothelial growth factor A | +3.1 | |
| PDGFA | Platelet-derived growth factor A | −2.0 | |
| Matrix metalloproteinases | MMP1 | Breakdown of extracellular matrix in embryonic development and reproductive tissue remodeling. | +9.2 |
|
|
MMP2
|
| +3.6 |