TABLE 2

The role of adenosine A2A receptors in cAMP superactivation 3 h after withdrawal

NAc/striatal neurons were treated with 100 nM morphine for 18 h. Three hours after withdrawal (W.D.), cells were then treated with or without adenosine deaminase (ADA, 1 unit/ml) or the A2A antagonist KW-6002 (100 nM) for 2 h. Data are the mean ± S.E.M. of at least three experiments with each treatment carried out in triplicates.


Treatment

cAMP Increase
%
W.D. 75 ± 7
W.D. + ADA 79 ± 11
W.D. + KW-6002
70 ± 6