TABLE 1

Gene loci and organ distribution of organic anion transporters (OATs)


Oat Isoform

Gene

Gene Locus

Amino Acid Length

Endogenous Substrates

Tissue and [Membrane] Localization

Other Identified Homologs
hOAT1 SLC22A6 11q13.1-13.2 506-563 α-Ketoglutarate, urate, PGE2, PGF, folate, nicotinate, xanthine, hypoxanthine, neurotransmitter metabolites (5-methoxyindole-3-acetate, homovanillate, vanilmandelate, 3,4-dihydroxyphenyl acetate, 5-hydroxyindole-3-acetate, N-acetyl-5-hydroxytryptamine, melatonin) Kidney [BL] Rat, mouse, flounder, pig, rabbit, monkey, Caenorhabditis elegans
Brain [U]
Placenta [U]
hOAT2 SLC22A7 6p21.2-21.1 546 and 548 cAMP, propionate, DHEAS, ES, PGE2, PGF, l-ascorbate, α-ketoglutarate Kidney [BL] Mouse, rat
Liver [SM]
hOAT3 SLC22A8 11q11.7 542 α-Ketoglutarate, cAMP, cortisol, PGE2, PGF, DHEAS, ES, taurocholate, urate, estradiol-17 β-glucuronide Kidney [BL] Rat, mouse, pig, rabbit, monkey
Brain [LM]
Adrenals [U]
Skeletal muscle [U]
Developing bone [U]
hOAT4 SLC22A11 11q13.1 550 ES, DHEAS, estrone, 17β-estradiol-3-sulfate, PGE2, PGF, octanoate, succinate, cholate, urate, taurocholate Kidney [LM]
Adrenals [U]
Placenta [BL]
mOat5 slc22a19 19 551 ES, DHEAS Kidney [LM] Rat
mOat6 slc22a20 19 556 ES, propionate, methylbutyrate, benzoate, heptanoate, 2-ethylhexanoate, pyruvate, PGE2 Olfactory mucosa [U] Human, rat
Testis [U]
hOAT7 SLC22A9 11q13.1 553 ES, β-estradiol sulfate, DHEAS, butyrate, propionate, valerate, caproate, lactate, nicotinate, acetate Liver [SM]
hOAT10 SLC22A13 3p21.3 551 Nicotinate, urate, succinate, l-lactate, glutarate Kidney [LM]
Brain [U]
Heart [U]
Colon [U]
hURAT1
SLC22A12
11q13.1
332 and 553
Urate, acetoacetate, succinate, β-hydroxybutyrate, lactate, nicotinate, α-ketoglutarate
Kidney [LM]
Mouse
  • hOAT, human organic anion transporter; mOat, mouse organic anion transporter; PGE2, prostaglandin E2; PGF2α, prostaglandin F2α, DHEAS, dehydroepiandrosterone sulfate; ES, estrone-3-sulfate; BL, basolateral membrane; U, undetermined; SM, sinusoidal membrane; LM, luminal membrane.