[3H]Almorexant Competition Binding (37°C) | ||||
---|---|---|---|---|
OX Antagonists | hOX1 | hOX2 | ||
Ki | nH | Ki | nH | |
nM | nM | |||
Almorexant | 4.7 ± 0.9 | 1.1 ± 0.1 | 0.9 ± 0.0 | 1.3 ± 0.0 |
Cp-1 | 25.7 ± 1.8 | 0.8 ± 0.1 | 0.7 ± 0.0 | 1.0 ± 0.0 |
Cp-2 | 3.3 ± 0.8 | 1.5 ± 0.1 | 2.4 ± 0.1 | 1.1 ± 0.0 |
Cp-3 | 8.4 ± 2.2 | 1.3 ± 0.1 | 5.1 ± 0.4 | 1.0 ± 0.0 |
SB-674042 | 1.9 ± 0.5 | 1.8 ± 0.2 | 133.5 ± 53.0 | 0.8 ± 0.0 |
SB-408124 | 32.7 ± 1.8 | 2.1 ± 0.7 | 1850 ± 670.0 | 1.8 ± 0.5 |
SB-334867 | 41.6 ± 2.8 | 1.9 ± 0.1 | 6300.0 ± 2000.0 | 0.8 ± 0.0 |
EMPA | 4533 ± 1580 | 0.9 ± 0.1 | 1.2 ± 0.1 | 1.0 ± 0.0 |
Cp-4 | 782.0 ± 212.0 | 1.1 ± 0.0 | 3.86 ± 0.3 | 1.1 ± 0.1 |
Cp-5 | >10,000 | 33.4 ± 2.3 | 0.8 ± 0.0 |