Effect of OX1 and OX2 antagonists on basal and orexin-A-induced increase of firing frequency of DA neurons in the VTA
All compounds were tested at 1 μM according to the experimental procedure shown in Fig. 9.
| OX Antagonist | Basal Firing Frequency | Increase of Firing Frequency | Reversal of Orexin-A Effect | n | ||
|---|---|---|---|---|---|---|
| Control | + Antagonist | Orexin-A | Orexin-A + Antagonist | |||
| Hz | % control | % | ||||
| Almorexant | 2.43 ± 0.8 | 2.52 ± 0.7 | 170 ± 29 | 105 ± 2 | 89 ± 5 | 5 |
| EMPA | 1.57 ± 0.34 | 1.45 ± 0.32 | 150 ± 20 | 104 ± 2 | 89 ± 7 | 6 |
| SB-408124 | 2.89 ± 0.44 | 2.99 ± 0.37 | 161 ± 17 | 131 ± 14 | 62 ± 13 | 5 |
| SB-674042 | 2.47 ± 0.48 | 2.47 ± 0.48 | 163 ± 8 | 129 ± 8 | 57 ± 9 | 5 |