TABLE 1 Mean single-channel parameters for wild-type α1β1γ2s and mutant α1β1γ2s(L287A) receptors
PRO increased the mean single-channel burst open time and mean burst Po only in mutant receptors. In the absence of PRO, mutant receptors had a higher mean burst closed time and lower mean burst Po than wild-type receptors. In the presence of PRO, mutant receptors had the highest mean burst open time and mean burst Po of the four conditions. The total numbers of patches for each condition were as follows: WT − PRO, 7; WT + PRO, 6; MUT − PRO, 7; MUT + PRO, 8.