Biological Event | Experimental System | Sprouty Isoform(s) | Growth Factor/Ligand | References |
---|---|---|---|---|
Placental villi sprouting | Placenta | hSpry1, -2, -3 | FGF4, FGF10 | Anteby et al., 2005 |
Placental villi sprouting | Placenta | hSpry2 | FGF10 | Natanson-Yaron et al., 2007 |
Kidney development | Embryonic kidney explants | mSpry1 | Gross et al., 2003 | |
Ureteric branching | spry-null mice | mSpry1 | Gdnf/Ret/Wnt11 | Basson et al., 2005, 2006 |
Ureteric branching | Kidney transgenic mice | hSpry2 | Wnt11FGF 7/Gdnf | Chi et al., 2004 |
Kidney development | Human renal mesenchymal cells | hSpry4 | LIF/FGF2/TGFα | Price et al., 2007 |
Male sex organogenesis | Testes | mSpry2 | FGF9 | Chi et al., 2006 |
Neuronal differentiation | Immature neurons | mSpry2 | BDNF | Gross et al., 2007 |
Muscle regeneration | Soleus muscle | hSpry1, -2, -4 | FGF6 | Laziz et al., 2007 |
Pancreas development | Pancreatic beta cells | mSpry4 | Jäggi et al., 2008 |
LIF, leukemia inhibitory factor; BDNF, brain-derived neurotrophic factor.