EGF | FGF | PDGF | VEGF | |
---|---|---|---|---|
Sprouty1 | ↑↔ | ↓↔ | ? | ↓ |
Egan et al., 2002; Ozaki et al., 2005 | Hanafusa et al., 2002; Yusoff et al., 2002; Ozaki et al., 2005 | Impagnatiello et al., 2001; Huebert et al., 2004 | ||
Sprouty2 | ↑↔ | ↓ | ↓ | ↓ |
Fürthauer et al., 2001; Egan et al., 2002; Wong et al., 2002; Ozaki et al., 2005 | Fürthauer et al., 2001; Impagnatiello et al., 2001; Yusoff et al., 2002; Ozaki et al., 2005 | Kajita et al., 2007 | Impagnatiello et al., 2001 | |
Sprouty3 | ? | ? | ? | ? |
Sprouty4 | ↔ | ↓↔ | ? | ↓ |
Fürthauer et al., 2001; Sasaki et al., 2003; Ozaki et al., 2005 | Fürthauer et al., 2001; Lee et al., 2001; Yusoff et al., 2002; Ozaki et al., 2005 | Lee et al., 2001; Sasaki et al., 2003 |
PDGF, platelet-derived growth factor; ↑, overexpression of sprouty-activated ERK activation; ↓, overexpression of sprouty-inhibited ERK activation; ↔, overexpression of sprouty did not affect ERK activation; ?, no current reports.